Alpha-2 Macroglobulin Arthritis Injection Therapy

What is an alpha-2 macroglobulin injection?

Also known as A2M, alpha-2 macroglobulin is a human plasma protein molecule that occurs naturally in your bloodstream. It is derived from a sample of your own blood, which is separated into red and yellow plasma. The yellow plasma is then concentrated to increase the number of A2M protein molecules, which are then injected into your joint. It works to reduce inflammation, promotes the growth of health tissue and may even stop the progression of osteoarthritis.

Alpha-2 macroglobulin injection - California

What types of conditions are treated with alpha-2 macroglobulin?

A simple biomarker test determines if you are a candidate for A2M therapy. The following conditions are appropriate for alpha-2 macroglobulin therapy:

  • Osteoarthritis (knee and hip, as well as the lumbar and sacral spine)
  • Labral tear
  • Meniscus tear
  • Neck and spine injuries
  • Sciatica
  • Degenerative disc disease
  • Herniated or slipped disc
  • Coccydynia

How does alpha-2 macroglobulin therapy work?

A2M is known as a broad-spectrum multi-purpose protease inhibitor. This means that it can bind to and deactivate the enzymes that are responsible for cartilage degeneration within the joint. It is the only biologic treatment for arthritis-related conditions that can halt cartilage degeneration and prevent future damage.

Is alpha-2 macroglobulin therapy covered by insurance?

A2M therapy is not yet covered by health insurance.

How quickly can I get back to my regular routine after alpha-2 macroglobulin therapy?

A2M therapy may initially cause mild swelling or stiffness within the first week after your injection. You will need to refrain from strenuous activity and air travel during this week as well. Physical therapy is typically recommended to begin one week after treatment.

Are there any side effects to alpha-2 macroglobulin injections?

A2M therapy is safe because your own blood is used in the treatment, which eliminates the chance of a blood-borne disease or other related side effects. As will all injections there is a very small risk of infection at the injection site.

For more information or to schedule an appointment, contact West Coast Orthopedics today.

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